Pfizer Senior Associate Scientist, Formulations in Cambridge, Massachusetts
The key purpose of this position is to support experimental evaluation and formulation development of early candidate small molecule substrate. The Sr. Associate Scientist will be required to generate key physical-chemical, in vitro and formulation performance data. The Sr. Associate Scientist will also conduct pre-formulation and formulation experiments and generate data that will be used to influence Discovery teams based in Cambridge, MA finding NCEs with desirable drug delivery and performance properties. This position will include generation and assessment of in silico , in vitro and in vivo data as well as design of stage appropriate formulations for preclinical studies. An awareness of organic chemistry, physical chemistry, analytical chemistry and as well as an understanding of various analytical instrumentation is desired.
Conducts and optimizes routine laboratory or pilot-scale physicochemical experiments e.g. HPLC, spectroscopy, excipient and materials compatibility, dosage form processing, solubility determinations, process development studies, dissolution testing, freeze-dry processing, suspension processing etc.
Support the development and preparation of fit for purpose preclinical fomulations (traditional and enabling) to enable robust candidate selection and progression
Analyses data summarizes findings in reports and electronic notebook
Works under moderate supervision with regular review of achievement of results and methods used;identifies issues, seeks and evaluates options to design experiments and solve problems with particular practical situations within their competency; identifies issues, seeks and evaluates options to design experiments and solve problems with particular practical situations within their competency.
Utilizes technical knowledge to design or control experiments (e.g. polymorph bridging experiments, selection of excipients grades or processing conditions.); develops own protocols, orders materials, books equipment required to complete the the task
Independently performs experiments/operates equipment; issues technical reports and technical presentations after review from supervisor; uses established procedures, technologies, and methodologies; frequently reduces to practice novel approaches.
Assesses test methods, procedures, processes, etc. to identify improvements and alternative approaches with appropriate
guidance and use of the literature.
Supports novel research into in vitro formulation performance, novel drug delivery systems; able to adopt new technologies and procedures and apply to their work.
BS is science field such as Pharmaceutics, Chemistry, Medicinal Chemistry, Physical Chemistry or Biophysics with 2-4 years of relevant experience of working in a research laboratory.
Strong background and understanding of basic principles of physical, organic and analytical chemistry
Ability to independently conducts and optimizes routine laboratory or pilot-scale physicochemical experiments e.g. HPLC, spectroscopy, excipient and materials compatibility, dosage form processing, solubility determinations, process development studies, dissolution testing, freeze-dry processing, suspension processing
Ability to analyze experimental data and write summary reports. Ability to present data and technical summary to project teams
Other Job Details:
Last Date to Apply for Job: March 27, 2018
Additional Location Information: Cambridge, MA (Kendall Square)
Eligible for Employee Referral Bonus: Yes
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